PN-III-P4-ID-PCCF-2016-0112
Multifunctional magnetoplasmonic nanomaterials for point of care applications
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Objectives:

1-stStage

The design of functional magnetic nano-hybrids having a core-shell structure (magneto-plasmonic nanoparticles and magneto-plasmonic liposomes) that have improved magnetic, plasmonic and recognition properties

2-ndStage

Synthesis of magnetic core nanoparticles with controllable properties, development of methods of preparation of core-shell nanoparticles, study of physico-chemical properties and evaluation of biocompatibility.

3-rd Stage

Biofunctionalization of multifunctional magnetic hybrids with modified aptamers for selective recognition of tumor-derived exosomes.

4-th Stage

Magnetic isolation of TEX, detection and quantification of exosome content in serum samples.

5-th Stage

Validation of the concept of detection in clinical practice by incubating biofunctionalized hybrid nanoparticles with aptamers with serum samples taken from patients diagnosed with AML.


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