Aptamers are single-stranded oligonucleotides (DNA or RNA ) with specific three-dimensional conformation that can bind targets with high affinity and specificity. The main advantages of aptamers over antibodies is their small size, facile chemical synthesis and lack of imune response. The gold plasmonic shell on top of the magnetic core allows a better functionalization of the nanoparticles with -SH modified aptamers while the magnetic core enables magnetic field mediated isolation of TEX from blood samples. The aproach has a high degree of novelty due to the use of magneto/plasmonic nanoparticles for TEX isolation and due to the use of aptamer mediated recognition of myeloid leukemia specific antigens (CD 117) present in the exosomal membrane. The validation of the concept will be done using different controlled mixtures of exosomes for set-up calibration, follewed by tests in the clinical setting using AML pacients derived blood samples.